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A New Era in Anti-Infectives

 

The following data is based upon testing done on the Microcyn® Technology platform and does not necessarily infer that similar data would be generated in testing on various Microcyn-based products or formulas under development.

MIcrocyn Technology

Publications

Allie D. Super-Oxidized Dermacyn in Lower-Extremity Wounds. Wounds 2006, 18 (Suppl), 3-6.

Anand, Ashok Comparative Efficacy and Tolerability of Oxum against Povidone Iodine Topical Application in the Post-caesarean Section Wound Management Indian Medical Gazette December 2007, 498-505.

Barrera-Zavala A, Guillen-Rojas M, Escobedo-Anzures J, Rendon J, Ayala O & Gutiérrez AA. A pilot study on source control of peritonitis with a neutral pH – super oxidized solution. Submitted 2008.

Bongiovanni CM. Superoxidized Water Improves Wound Care Outcomes in Diabetic Patients Diabetic Microvascular Complications Today 2006, May-Jun: 11-14.

Bongiovanni CM Nonsurgical management of chronic wounds in diabetics. The Journal of Vascular Ultrasonography 2006, 30: 215-218.

Dalla Paola, L. Treating diabetic foot ulcers with super-oxidized water. Wounds. 2006, 18 (Suppl), 14-16.

Dalla Paola L, Brocco E, Senesi A, Ninkovic S, Mericvo M & De Vido D. Use of Dermacyn, a new antiseptic agent for the local treatment of diabetic foot ulcers, J Wound Healing 2005, 2:201.

Dalla Paola L, Brocco E, Senesi, A, Merico M, De Vido D, Assaloni R, DaRos R. Super-Oxidized Solution (SOS) Therapy for Infected Diabetic Foot Ulcers. Wounds, 2006 18: 262 – 270.

Dalla Paola L & Faglia E.Treatment of Diabetic Foot Ulcer: An Overview. Strategies for Clinical Approach Current Diabetes Reviews, 2006, 2, 431-447 431

Fanggang N, Guoan Z. The clinical efficacy of Dermacyn on deep partial thickness burn wounds. Submitted in China 2008.

Flores-Martínez MA. Super-Oxidized Solution (SOS) Therapy for Root Canal Infections. Oculus Innovative Sciences archives. 2005.

Gutiérrez AA. The Science Behind Stable, Super-Oxidized Water. Exploring the various applications of super-oxidized solutions. Wounds. 2006, 18 (Suppl), 7-10.

González-Espinosa D, Pérez-Romano L, Guzman Soriano B, Arias E, Bongiovanni CM & Gutiérrez AA. Effects of neutral super-oxidized water on human dermal fibroblasts in vitro. Int Wound Journal (UK) 2007, 4: 241-250.

Goretti C, Mazzurco S, Ambrosini Nobili L, Macchiarini S, Tedeschi A, Palumbo F , Scatena A, Rizzo L and Piaggesi A. Use of a novel antiseptic super-oxidised solution (sos) in the management of wide post-surgical lesion in the infected diabetic foot. Int J Low Extrem Wounds 2007, 6:22-27.

Hadi SF, Khaliq T, Bilal N, Sikandar I, Saaiq M, Zubair M, Aurangzeb S. Treating infected diabetic wounds with superoxidized water as anti-septic agent : a preliminary experience. J Coll Physicians Surg Pak. 2007, Vol. 17 (12):740-743

Landa-Solis C, González-Espinosa D, Guzman B, Snyder M, Reyes-Terán G, Torres K and Gutiérrez AA. Microcyn TM a novel super-oxidized water with neutral pH and disinfectant activity. J Hosp Infect (UK) 61: 291-299.

Landsman A, Blume P, Jordan D, Vayser DJ, Halperin G, Gutierrez AA and Oculus Collaborative Group. An Open-Label, Three-Arm, Pilot Study Of The Safety And Clinical Efficacy Of Topical Dermacyn Wound Care Versus Oral Levofloxacin Versus Combined Therapy For Mild Diabetic Foot Infections. In preparation.

Le Duc Q, Breetveld M, Middelkoop E, Scheper RJ, Ulrich MMW, Gibbs S. A cytotoxic analysis of antiseptic medication on skin substitutes and autograft. Br J Dermatology. 2007, 157:33-40.

Martínez de Jesús, F. Sterilant for human wounds is changing patient’s lives. Infection Control Today. 2004, 11(8).

Martínez-De Jesús FR, Ramos-De la Medina A, Remes-Troche JM, Armstrong DG, Wu SC, Lázaro Martínez JL, Beneit-Montesinos JV. Efficacy and safety of neutral pH superoxidised solution in severe diabetic foot infections. Int Wound J. 2007, 4:353-362.

McCurdy B. Emerging Innovations in Treatment. Podiatry Today 2006, 19: 40-48.

Medina-Tamayo J, Balleza-Tapia H, López, X, Cid, ME, González-Espinosa, D. Gutiérrez AA., and González-Espinosa C. Super-oxidized water inhibits IgE-antigen- induced degranulation and cytokine release in mast cells.International Immunophamacology 2007, 7:1013-1024

Miranda-Altamirano A. Reducing Bacterial Infectious Complications from Burn Wounds. A look at the use of Oculus Microcyn60 to treat wounds in Mexico. Wounds 2006, 18 (Suppl), 17-19.

Paul M, Setlow B & Setlow P.The killing of spores of Bacillus subtilis by Microcyn™, a stable superoxided water. Submitted 2008.

Paz J. Estudio comparativo en procedimientos quirúrgicos del área de cirugía oral y maxilofacial sustituyendo solución salina de irrigación por solución electrolítica de pH neutro. Oculus Innovative Sciences archives. 2004.

Rose R, Setlow B, Monroe A, Mallozzi M, Driks A, Setlow P. Comparison of the properties of Bacillus subtilis spores made in liquid or on agar plates. Submitted 2006.

Steenvoorde P, van Doorn LP, Jacobi CE, Oskam J.An unexpected effect of Dermacyn on infected leg ulcers. J Wound Care. 2007 , 16:60-61

Suri AP. The Effectiveness of Stable Neutral Super-oxidized Solution for the Treatment of Infected Diabetic Foot Wounds. Submitted Jan, 2008.

Wolvos TA. Advanced Wound Care with Stable, Super-Oxidized Water. A look at how combination therapy can optimize wound healing. Wounds 2006, 18 (Suppl), 11-13.

Veverkova L, Jedlicka V, Vesely M, Tejkalova R, Zabranska S, Capov I, Votava M. Methicilin-resistent Staphylococcus aureus –problem in health care. J Wound Healing 2005, 2:201-202.

Zahumensky E. Infections and diabetic foot syndrome in field practice. Vnitr Lek. 2006;52:411-416.

Presentation at Congresses

Allie D. Super-Oxidized Dermacyn in Lower-Extremity Wounds.

New Cardiovascular Horizons. Miami Fla., USA. 2-4 Nov. 2005

Diabetic Foot Global Conference. Hollywood, Ca. 23rd-25th March. 2006

Symposium on Advanced Wound Care & Medical Research Forum on Wound Repair. San

Antonio, Texas. 30th Apr- 1 May, 2006

APWCA, Fort Worth, Texas. US. March 6-9, 2008.

Barrera-Zavala A, Guillen-Rojas M, Escobedo-Anzures J, Rendon J, Ayala O & Gutiérrez AA. A pilot study on source control of peritonitis with a neutral pH – super oxidized solution

XV Reunion Nacional de Cirugia (AEC) Sevilla, España 25th-28th Oct, 2005-09-22

29º Congreso Mexicano de Cirugía, Federación Latinoamericana de Cirugía Mérida,

Yucatán. México 30th Oct- 4th Nov, 2005

16th World Congress of the International Association of Surgeons and

Gastroenterologists (IASG). Madrid, Spain. 25th-27th May, 2006.

Bogiovanni C. Bomengen RW, Hughes MD. Superoxidized solution: spectrum of clinical applications

Diabetic Foot Global Conference. Hollywood, Ca. 23rd-25th March. 2006

New Cardiovascular Horizons. New Orleans, Lo. 5-8 September, 2007

Dalla Paola, E. Brocco, A. Senesi, S.Ninkovic, M. Merico, D.DeVidoUse of dermacyn™, a new antiseptic agent, for the local treatment of diabetic foot ulcers.

Diabetic Foot Global Conference. Hollywood, Ca. 3rd-5th March. 2005.

13th Practical Diabetes International Annual Diabetic Foot Conference Royal College of

Physicians, London, 5th July, 2005.

5th Annual meeting. Diabetic Foot Study Group 2005 Greece, 7-10th Sept. 2005

DGFW European Wound Healing Meeting. 2005. Stuttgart. 15-17th Sept, 2005

Controversy or consensus in the diabetic foot, London. 10th-11th Oct, 2005

Wounds UK 2005, Harrogate UK. 14th-16th October, 2005

New Cardiovascular Horizons. Miami Fla., USA. 2-4 Nov. 2005

Diabetic Foot Global Conference. Hollywood, Ca. 23rd-25th March. 2006

11th Malvern International Diabetic Foot Meeting, Malvern. 17th-19th May 2006

Dardine J, Martinez C, & Thatcher E. Activity of a pH Neutral Super-Oxidized Solution Against Bacteria Selected for Sodium Hypochlorite Resistance. 47th ICAAC Meeting. Poster L-1144. Chicago, Ill. USA. Sept 17-20,2007.

Frykberg RG, Tallis A, Tierney, E. : Wound Healing in Chronic Lower Extremity Wounds Comparing Super-Oxidized Solution (SOS) vs. Saline . Diabetic Foot Global Conference. Hollywood, Ca. 13-15 March. 2008.

Frykberg RG, Tallis A, Tierney, E. Reduction of Bacterial Burden in Chronic Wounds in Patients with Diabetes Mellitus Using a Novel Topical Superoxidized Solution. Symposium on Advanced Wound Care and Wound Healing Society, San Diego, CA, April 24-28, 2008

Gauland C. Sickle cell disease. Wounds. Symposium on Advanced Wound Care and Wound Healing Society, San Diego, CA, April 24-28, 2008

González D, Pérez L, Guzmán B, Arias E, Bongiovanni Ch, Gutiérrez AA. Effects of pH Neutral, Super-Oxidized Solution On Human Dermal Fibroblasts In Vitro . 47th ICAAC Meeting. Poster L-1144. Chicago, Ill. USA. Sept 17-20,2007.

Gutiérrez AA. The Science Behind Microcyn

5th Annual meeting. Diabetic Foot Study Group 2005. Greece, 7-10th Sept. 2005

New Cardiovascular Horizons. Miami Fla., USA. 2-4 Nov. 2005

2nd Diabetes India International Conference. BM Birla Convention Centre, Jaipur India. Nov 19, 2005

Northwest Society of Plastic Surgeons. 44th Annual Scientific Meeting. Whistler, Canada. 2006

New Cardiovascular Horizons. New Orleans, Lo. 5-8 September, 2007

Landsman A, Blume P, Palladino M, Jordan D, Vayser DJ, Halperin G, Gutierrez AA and Oculus Collaborative Group. An Open Label, Three Arm Study of the Safety and Clinical Efficacy of Topical Wound Care vs. Oral Levofloxacin vs. Combined Therapy for Mild Diabetic Foot Infections. Diabetic Foot Global Conference. Hollywood, Ca. 13-15 March. 2008

Martínez de Jesús, F. A prospective, randomized, single blinded study with neutral pH- super oxydized water in diabetic patients with infected feet ulcers.

Diabetic Foot Global Conference. Hollywood, Ca. 3rd-5th March. 2005

28º Congreso Mexicano de Cirugía, Federación Latinoamericana de Cirugía Leon, Guanajuato, México Nov, 2004

Martínez-Munive A., Menéndez-Skertchly A., Toiber M., Hernández-Hernández B., Padilla-Longoria R., Quijano-Orvananos F. Super-oxidized water (Microcyn 60) for mesh hernioplasty in grossly contaminated fields: an experimental study. SE 163.

Hernia Repair. 2005. American Hernia Society. San Diego, CA, USA. February 9-12, 2005.

American College of Surgeons 91st Annual Clinical Congress. San Francisco, CA. USA. October 16-20, 2005.

Miranda Altamirano A., Medina Preciado D, Chavez Velarde TJ, et al.. Treatment of 2nd & 3rd Degree Burns in 64 Pediatric Patients Without Routine Antibiotics using New “Super-oxidized Water Technology” Dermacyn™.

Texas Surgical Society Congress. San Antonio, Tx. 1st-3rd April, 2005.

XXV Congreso Nacional de la Asociación Mexicana de Quemaduras. Guanajuato, Guanajuato, México. April 2005

VI Congreso Latinoamericano de Quemaduras. La Habana, Cuba. May 2005

European Burns Association Meeting 2005 Estoril Portugal. 21st-24th Sept, 2005

New Cardiovascular Horizons. Miami Fla., USA. 2-4 Nov. 2005

Northwest Society of Plastic Surgeons. 44th Annual Scientific Meeting. Whistler, Canada. 2006

Monaghan BT & Cundell JH. Dermacyn as the Local Treatment for Infected Diabetic Foot Wounds. A case series. 5th Int. Symp. On the Diabetic Foot. Noordwijkerhout. 2007, The Netherlands. May 9-12, 2007-

Ojeda VG, Tort MA, Rivera VA, Padilla MC. Prevención de la infección de las heridas de espesor parcial con tratamiento mediante solución superoxidada (Microcyn 60). 28º Congreso Mexicano de Cirugía, Federación Latinoamericana de Cirugía Leon, Guanajuato, México Nov, 2004

Peterson D, Hermann K, Niezgoda J, Dermacyn Effective in Treatment of Chronic Wounds with Extensive Bioburden While Reducing Local Pain Levels. Symposium on Advanced Wound Care and Wound Healing Society, Tampa, FL, April 28-May1, 2007

Piaggesi A, Goretti C, Scatena A, Tedeschi A, Palumbo F, Campi F, Rizzo L.. Effectiveness of Dermacyn® in the treatment of infected foot wounds

La gestione del piede diabetico negli anni 2000: Il ruolo dell’ equipe. Firenze, 5-7 Dicembre 2005

Diabetic Foot Global Conference. Hollywood, Ca. 23rd-25th March. 2006

17th Conference. EWMA Meeting 2005. Glasgow, UK. May 2-4, 2007.

Piaggesi A, Goretti C, Mazzurco S, Scatena A, Tedeschi A, Rizzo L. Efficacy and safety of microcyn® technology in wide post-surgical lesions in the infected diabetic foot. Diabetic Foot Global Conference. Hollywood, Ca. 13-15 March. 2008

Piaggesi A, Goretti C, Mazzurco S, Scatena A, Tedeschi A, Rizzo L. Efficacy And Safety Of A Novel Super−Oxidized Solution (SOS) In Managing Post−Surgical Lesions Of The Diabetic Foot: A Prospective, Randomized Clinical Trial. World Union Of Wound Healing Societies. Toronto, Canada. June 4-8, 2008.

Ramaswami G, Kerrigan K, Boysen D, The Role of Super-Oxidized Antiseptic Solution in Wound Treatment. Symposium on Advanced Wound Care and Wound Healing Society, Tampa, FL, April 28-May1, 2007

Ramirez Cadena, C. Super Oxidized - non.toxic solution (Microcyn 60) for the adjuvant therapy in the healing of venous ulcers. 28º Congreso Mexicano de Cirugía, Federación Latinoamericana de Cirugía Leon, Guanajuato, México. Nov, 2004

Regulski M, Floros R, Petranto R, Migliori V, Alster H, Pfeiffer D. Efficacy and Compatibility of Dermacyn® Solution with OASIS® Matrix for the Treatment of Venous Ulcers, Post-Traumatic and Post-Surgical Wounds. New Cardiovascular Horizons. New Orleans, Lo. 5-8 September, 2007

Regulski M, Floros R, Petranto R, Migliori V, Alster H, Pfeiffer D. Efficacy and Compatibility of Combination Therapy with Super-Oxidized Solution*and a Skin Substitute§ for Lower Extremity Wounds. Symposium on Advanced Wound Care and Wound Healing Society, San Diego, CA, April 24-28, 2008

Ricci E, Astolfi S, Cassino R. Clinical results about an antimicrobial solution (Dermacyn® Wound Care) in the treatment of infected chronic wounds. 17th Conference. EWMA Meeting 2005. Glasgow, UK. May 2-4, 2007.

Sanchez−Miranda E, Gonzalez Espinosa D, Gutierrez AA, Gonzalez−Espinosa C. Anti inflammatory effects of an oxychlorine compound in a murine model of passive cutaneous anaphylaxis. World Union Of Wound Healing Societies. Toronto, Canada. June 4-8, 2008.

Suri AP. The Effectiveness of Stable Neutral Super-oxidized Solution for the Treatment of Infected Diabetic Foot Wounds. Diabetic Foot Global Conference. Hollywood, Ca. 13-15 March. 2008

Taketa-Graham M, Gutierrez AA, Thatcher E. The Anti-Viral Efficacy of a New Super-Oxidized Solution. 47th ICAAC Meeting. Poster L-1144. Chicago, Ill. USA. Sept 17-20,2007.

Thatcher E & Gutiérrez AA. The Anti-Bacterial Efficacy of a New Super-Oxidized Solution. 47th ICAAC Meeting. Chicago, Ill. USA. Sept 17-20,2007.

Uribe F, Sanchez FS. Comparative study of the use of jetox and chloride of sodium 0.9% versus jetox and solutions superoxidants electrolyzed. 19th Symposium on Advanced Wound Care and Wound Healing Society, San Antonio, Texas. 2006.

Uribe, F. – Effect of neutral pH SOS in the healing of Diabetic Foot Ulcers – ETRS Meeting – September 2007

Uribe F. Effect of neutral pH Superoxidized solution in the healing of diabetic foot ulcers. 47th ICAAC Meeting. Poster L-1144. Chicago, Ill. USA. Sept 17-20,2007.

Veverkova L, Jedlicka V, Vesely M, Tejkalova R, Zabranska S, Capov I, Votava M. Methicilin-resistent Staphylococcus aureus –problem in health care. European Wound Conference. Stuttgart, Germany. September 15-17, 2005.

Wolvos T. Advanced Wound Care with Stable, Super-Oxidized Water. New Cardiovascular Horizons. Miami Fla., USA. 2-4 Nov. 2005